Mimicking opioid analgesia in cortical pain circuits
Sample sizesThe sample sizes were not statistically determined before the experiments. Rather, the group sizes were on the basis of published literature for the type of manipulation (chemogenetics, site-specific genetic knockout and pharmacology) and measured outcome (such as pain behaviours) published in the field and/or by the authors involved2,28,64,66. The sample sizes for all experiments are included in the figure...









